What is Zidovir (Retrovir)?
Zidovir 300 mg is an antiretroviral agent used to treat human immunodeficiency virus (HIV) infections. Each Zidovir tablet contains 300mg of zidovudine, a nucleoside reverse transcriptase inhibitor (NRTI) that inhibits the viral replication of HIV, controlling the viral load in the blood.
The recommended daily dosage of Zidovir varies depending on your age group and health status. Take 300mg twice daily, or as instructed by your healthcare provider. The dose for pediatric patients is based on body weight. Patients who are pregnant are recommended to take 100mg 5 times daily. Do not change your dose unless specified by your doctor. Increasing or decreasing your dose can change the effect of the medication.
Do not take Zidovir if you are allergic to zidovudine.
Zidovir Side Effects
Some of the reported side effects of this treatment include:
- Upset stomach;
- Loss of appetite;
- And rash.
Rare side effects may include:
- Lactic acidosis, which is characterized by yellowing of the skin and sclera, unusual muscle pain, abdominal pain, weakness, fast or irregular heartbeat, loss of appetite, nausea and vomiting;
- Severe anemia or neutropenia, which is characterized by unusual bleeding or bruising, pale skin, and chills;
- And allergic reactions.
If you experience any adverse reactions, or any side effects worsen, contact your doctor to discuss your treatment.
If you have underlying medical conditions, this medication may exacerbate your symptoms or encourage the development of other health issues.
- Bone marrow suppression: This drug must be used with caution if you have compromised bone marrow. Pancytopenia, which is the deficiency of all 3 components of blood—red blood cells, white blood cells, and platelets—may also occur.
- Myopathy: This medical condition can be worsened when taking Zidovir. Use with caution.
- Lactic acidosis/severe hepatomegaly with steatosis: This potentially fatal medical disorder is marked by the accumulation of lactic acid in the blood, resulting in an abnormally low blood pH level. Certain patients, especially obese women with a history of liver disorders, should be cautious when taking this medication.
Inform your doctor of all medical conditions and medications you are taking prior to starting treatment with Zidovir. There is no known interaction with alcohol. You should speak to your doctor prior to consumption to determine whether this drug will be compatible with your lifestyle.
This medication may interact with certain medications, including:
- Ganciclovir, interferon alpha;
- Cytotoxic agents and bone marrow suppressive agents;
- And atovaquone.
Pregnancy & Lactation
This antiretroviral drug has been classified in category C of the FDA’s Pregnancy Risk Categories. As such, pregnant mothers must only use this drug if it is absolutely necessary. As well, it is not recommended to use this medication if you are breastfeeding unless necessary.
Previously reported cases of acute overdose in both adults and children have not been fatal; although, those patients experienced spontaneous or induced nausea and vomiting. If overdose occurs, contact a doctor.
Alternative Brand Names
This antiretroviral drug is also marketed internationally under the brand name Retrovir.
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