Tenvir-L is a medication used in combination with other medications to treat HIV. One Tenvir-L pill contains two antiretrovirals: 300mg of lamivudine and 300mg of tenofovir disoproxil fumarate. Tenvir-L cannot stop HIV from progressing to AIDS when taken alone; at least one other anti-HIV medication must be co-administered.
Patients should take one pill by mouth once a day.
Anyone with a history of hypersensitivity to lamivudine or tenofovir disoproxil fumarate should avoid Tenvir-L.
Adverse effects commonly reported by patients taking Tenvir-L include:
- peripheral neuropathy
- abdominal cramps
- depressive disorders
Less common side effects that have been documented are:
- renal impairment or failure
- tubular necrosis
- fanconi syndrome
- lactic acidosis
- proximal tubulopathy
Tenvir-L may cause other side effects including decreased bone density and redistribution of body fat. Inform your doctor is you noticed any changes in your health after starting Tenvir-L.
Anyone with a creatinine clearance less than 50 ml/min must not take Tenvir-L. Worsening of hepatic symptoms have been documented in patients with hepatitis B after they stopped taking Tenvir-L. For patients with hepatitis C, co-administering interferon alfa and ribavirin with Tenvir-L can heighten risks for hepatic decompensation. Use of didanosine is not recommended when beginning Tenvir-L because it can hinder Tenvir-L's effectiveness.
Taking nephrotoxic drug therapies with Tenvir-L can heighten risks of renal impairment. Drugs associated with peripheral neuropathy or pancreatitis including alcohol, sulfonamides, zalcitabine, stavudine, dapsone, isoniazid, and IV pentamidine should be taken with extreme precaution or avoided. Tenvir-L may heighten the risks of didanosine associated side effects. Lopinavir/ritonavir and atazanavir may worsen side effects associated with Tenvir-L. Tenvir-L should be discontinued if this occurs. Atazanavir without ritonavir must not be administered with Tenvir-L
Pregnancy & Lactation
Laboratory tests suggests that Tenvir-L can contaminate breast milk. Women with HIV should not breastfeed to prevent the risk of transmitting HIV to their infant.
Patients who take more Tenvir-L than prescribed should get medical attention right away for close monitoring. Activated charcoal can be used to purge the excess drug.
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