Tavin-L is taken with other antiretroviral medications to treat HIV. Each pill contains 300mg of tenofovir disoproxil fumarate and 300mg of lamivudine. Tavin-L must be taken with at least one other anti-HIV medication to stop HIV from progressing to AIDS.
Dosing and Administration
One tablet should be taken orally once a day.
Patients hypersensitive to tenofovir disoproxil fumarate or lamivudine should not take Tavin-L.
Common side effects associated with taking Tavin-L include:
- peripheral neuropathy
- depressive disorders
- abdominal cramps
Rarer adverse reacts documented include:
- renal impairment or failure
- proximal tubulopathy
- fanconi syndrome
- lactic acidosis
- tubular necrosis
Tavin-L may cause other adverse effects including redistribution of body fat and decreased bone density. Let a doctor know right away if you start to feel any physical or mental differences after beginning Tavin-L.
Precautions and Warnings
Patients with a creatinine clearance less than 50 ml/min should not take Tavin-L. Exacerbations of hepatic impairment have been reported by patients co-infected with hepatitis B after discontinuing Tavin-L. Patients with HCV taking interferon alfa and ribavirin may be at an increased risk of hepatic decompensation. Co-administration of didanosine and Tavin-L is not recommended for initial anti-HIV therapy because it can render Tavin-L ineffective in the early stages of treatment.
Concurrent use of nephrotoxic drug therapy may increase risks of renal impairment. Co-administrtion of drugs associated with pancreatitis or peripheral neuropathy such as alcohol, IV pentamidine, sulfonamides, dapsone, isoniazid, stavudine and zalcitabine should be avoided if possible or taken with precaution. Tavin-L can increase the risks of side effects associated with didanosine. Atazanavir and lopinavir/ritonavir can increase the risks of Tavil-L associated side effects. Tavin-L should be discontinued if side effects worsen. Co-administering atazanavir without ritonavir is not recommended.
Pregnancy and Breastfeeding
Tavin-L can contaminate breast milk. Mothers with HIV are discouraged from breastfeeding due to the risk of passing the virus to the child.
No specific antidote exists for Tavin-L. In the case of overdose, seek medical attention right away for monitoring. Activated charcoal may necessary to purge the drug.
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