What is Synthivan (Atazanavir/Ritonavir)?
Synthivan is an antiretroviral drug formulated by Cipla Limited, an award-winning Indian pharmaceutical company. This medication contains 2 active ingredients, 300mg of atazanavir sulfate and 100mg of ritonavir. These 2 components belong to a class of protease inhibitors that help to prevent human immunodeficiency virus (HIV) replications. Each bottle of Synthivan contains 30 tablets which must be stored in a cool and dry place.
The recommended oral dosage of Synthivan is determined based on a patient’s individual treatment history. Both therapy-naive and therapy-experienced patients may be prescribed 1 daily tablet, to be taken with food. For the best outcome, the drug must be taken daily.
This antiretroviral therapy is contraindicated in those with clinically significant hypersensitivity to atazanavir, ritonavir or other excipients present in the medication. It is also contraindicated from being co-administered with other drugs that require CYP3A or UGT1A1 for clearance.
Synthivan Side Effects
Common side effects include:
- Abdominal pain;
- Altered taste;
- Throat pain;
- Tingling or pricking sensation.
Severe side effects include:
- Maculopapular rash;
Always read the product information pamphlet for other possible side effects. Additionally, you should promptly seek medical attention if you display any of these symptoms.
Synthivan can cause severe health problems if a your underlying medical conditions are not assessed thoroughly. Some of the commonly documented health complications among Synthivan users include:
- Cardiac conduction abnormalities;
- Severe skin rashes;
- Liver toxicity;
- Chronic kidney disease.
Your doctor should be informed of your complete medical history (e.g. existing medical problems, medications and supplements taken, lifestyle behavior) to determine the best therapy for you.
Atazanavir and ritonavir, the 2 active ingredients in this antiretroviral medication, can interact with other drugs resulting in dangerous and potentially fatal reactions.
- Drugs that can interact with atazanavir:
- Antibiotics (e.g. rifampin);
- Antineoplastics (e.g. irinotecan);
- Benzodiazepines (e.g. triazolam);
- Gastrointestinal (GI) motility agents (e.g. cisapride);
- HMG-CoA reductase inhibitors (e.g. lovastatin, simvastatin);
- Non-nucleoside reverse transcriptase inhibitors (e.g. nevirapine).
- Drugs that can interact with ritonavir:
- Antianginal agents (e.g. ranolazine);
- Antifungals (e.g. voriconazole);
- Anti-gout agents (e.g. colchicine);
- Antipsychotics (e.g. lurasidone);
- Herbal products (e.g. St. John’s wort).
Read the product pamphlet thoroughly for more information on possible drug interactions and appropriate dosage adjustments. Do not change your dose without instructions from your doctor.
Pregnancy & Lactation
Both of the active ingredients are classified under category B in the Food and Drug Administration’s (FDA) pregnancy categories. It may only be prescribed if the potential benefits outweigh the potential risks.
There is limited human experience with acute atazanavir overdose. Healthy research subjects who had taken single doses of up to 1,200mg did not experience any health complications. However, a patient infected with HIV experienced an asymptomatic bifascicular block and PR interval prolongation following an atazanavir dose of over 29g. This resolved spontaneously. Similarly, there is limited human experience with acute ritonavir overdosage. A patient who self-administered 1,500mg daily for 2 days experienced paresthesia, which resolved once the dose was lowered. This suggests that the best management therapy for an overdose of Synthivan would be to engage general supportive measures, such as having your vital signs monitored.
Alternative Brand Names
Some alternative brands that share the same formulation as Synthivan are Virataz R and Anzavir R.
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