What is Stavir (Zerit)?
Stavir 30mg is an antiretroviral medication manufactured by Cipla Limited, an award-winning Indian company specializing in pharmaceutical products. This nucleoside analog reverse-transcriptase inhibitor (NRTI) contains 30mg of stavudine, which inhibits the replication of Human Immunodeficiency Virus (HIV) type 1 and 2. It is usually prescribed in combination with other antiretroviral agents to treat HIV-1 infections.
The dosage regimen of Stavir is determined based on body weight.
- Patients weighing less than 60kg: Take 40mg stavudine every 12 hours.
- Patients weighing greater than 60kg: Take 30mg of stavudine every 12 hours.
This drug can be taken with or without food. A missed dose should be taken as soon as you remember, unless it is already time for the next dose. If it is already time for your next dose, continue with the scheduled dose.
Patients who are allergic to stavudine or any of the components in the medication should not use Stavir.
Stavir Side Effects
Commonly reported side effects include:
- Tingling, pain, and numbness in the hands and feet;
Rarer side effects reported include:
- Blood in the urine;
- Fast or irregular heartbeat;
- Chest pain;
- And severe stomach pain.
Refer to the information pamphlet for more details on precautions and warnings.
Inform your doctor if you have kidney disease, gallstones, a pancreas disorder, or liver disease.
As well, inform your doctor if you experience the following:
- Lactic acidosis: This medical condition is characterized by the buildup of lactic acid in the blood, making the blood pH level abnormally low. Severe cases of lactic acidosis, including fatal ones, were observed in patients who are on antiretroviral nucleoside analogues together with stavudine and other antiviral agents. Besides that, the combination of stavudine with didanosine and hydroxyurea increases the risks of hepatotoxicity.
- Neurological disorder: Motor weakness has been reported in patients who are on antiretroviral therapy including stavudine. Peripheral neuropathy as marked by symptoms like numbness, tingling, and pain in the limbs have also been reported.
- Fat redistribution: Redistribution of body fat resulting in central obesity, breast enlargement, peripheral wasting, and facial wasting.
Patients with impaired renal or liver function must also be monitored to prevent the exacerbation of conditions. Refer to the information pamphlet for a complete list of precautions and warnings.
Zidovudine, another type of antiretroviral drug can competitively inhibit the actions of Stavir. Do not prescribe these 2 drugs concomitantly.
Pregnancy & Lactation
This drug is classified under Category C in Pregnancy Risk Categories; hence, it can only be prescribed for pregnant women if it is absolutely necessary. Clinical studies found that stavudine was excreted in the breast milk in animal subjects; however, it is not known whether this applies to humans. It is not recommended to breastfeed while taking this medication.
Patients who overdosed using 12 to 24 times the recommended daily dosage of Stavir did not show acute toxicity. That being said, patients may still display some signs of hepatic toxicity and peripheral neuropathy. If you have taken more than the recommended dose, contact your doctor or another medical professional immediately.
Alternative Brand Names
This drug is marketed in the US and Canada as Zerit.
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