Alternative Brand Names
Norvir is a popular HIV medication in the USA. Both Norvir and Ritomune contain ritonavir as their active ingredient, making Ritomune the most popular equivalent to Norvir in India.
Ritomune is used in combination with other antiretroviral medications to treat HIV. Each Ritomune pill contains 100mg of ritonavir. Other antiretrovirals must be co-administered with Ritomune to prevent HIV from progressing to AIDS.
The recommended adult dose is six pills, a total of 600mg of ritonavir, twice a day. Taking Ritomune on a full stomach and setting a titration schedule can improve tolerability. It is unknown if antacids inhibit absorption of Ritomune. Ritomune dosage may begin with 300mg twice daily to be increased by 100mg twice daily at two or three day intervals until reaching the optimal dose. If co-administered with saquinavir, no more than 400mg of saquinavir should be taken twice daily, and Ritomune intake can be decreased to 400mg twice daily. Safety of Ritomune in pediatric patients is currently being researched. If Ritomune is being used to boost protease inhibitors, a lower dose of Ritomune is advisable.
Patients with hypersensitivity to rotinavir should avoid Riotmune. Co-administering any of the following medications with Ritomune can result in serious and possibly fatal adverse effects: ergonovine, midazolam, pimozide, triazolam, amiodarone, neuroleptic, bepridil, flecainide, sisapride, quinidine, alfuzosin HCL, propafenone, astemizole, terfenadine, ergotamine, methylergonovine and dihydroergotamine.
Ritomune Side Effects
Side effects commonly reported by patients taking Ritomune include: vomiting abdominal pain anorexia asthenia diarrhea nausea taste perversion circumoral and peripheral paresthesias Rarer side effects include: malaise fever vasodilation dyspepsia headache constipation flatulence dizziness myalgia local throat irritation insomnia somnolence abnormal thinking sweating rash hyperglycemia pharyngitis hyperlipidemia increase in creatine phosphokinase hyperlipidemia diabetes mellitus increased bleeding in patients with hemophilia body fat redistribution and accumulation In rare instances, Ritomune may cause fatal pancreatitis. If pancreatic symptoms arise, seek help right away. Inform your doctor if you notice any health changes after starting Ritomune.
Immune reconstitution syndrome is common when beginning antiretroviral medications.
Ritomune may heighten plasma concentrations of drugs metabolized by the cytochrome P450 (CYP450) enzyme system and its isoforms. Delavirdine may affect plasma concentrations of Ritomune. Ritomune may decrease plasma concentrations of methadone, theophylline and didanosine. Ritoune may heighten plasma concentrations of ketoconazole, desipramine, rifabutin and clarithromycin. Ethinyl estradiol, found commonly in hormonal contraceptives, may inhibit Ritomune. Consider alternatives means of contraception. Ritomune can stregnthen the effects of sedatives such as diazepam, buspirone, clorazepate, zolpidem, flurazepam and estazolam. Ritomune can increase the risk of sildenafil, tadalafil and vardenafil associated side effects. Sildenafil dose should be capped at 25mg every 48 hours, tadalafil should be limited to 10mg each 72 hours and vardenafil should be limited to 2.5mg each 72 hours. Ritomune may cause disulfiram-like reactions when taken with disulfiram or metronidazole. Ritomune can increase the Cmin of saquinavir. Ritomune may cause seizures when co-administered with meperidine. Taking rifampin with Ritomune can make Ritomune stop working. Ritomune can legnthen the effects of trazodone. Ritomune can increase plasma concentrations of voriconazole to a dangerous level.
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