What is Nevimune (Nevirapine)?
Nevimune 200mg is an antiviral drug that is used to treat human immunodeficiency virus (HIV) infections. A single tablet contains 200mg of nevirapine, which acts as a non-nucleoside reverse transcriptase inhibitor (NNRTI). When HIV infects a susceptible target cell, the reverse transcriptase enzyme will integrate the genetic material from the virus into the host cell and undergo swift retroviral replication. If left untreated, the virus load will significantly increase, resulting in a weakened immune system. Subsequently, health complications, like infections and cancers, may emerge. Nevimune functions by blocking the activity of reverse transcriptase, preventing HIV from multiplying and thereby minimizing the chances of developing Acquired Immunodeficiency Syndrome (AIDS).
The proper dosage will depend on the severity of your condition. However, most patients are instructed to take 1 tablet daily for 14 days, followed by 1 tablet twice a day. If your dosage is interrupted for more than 7 days, you must restart the entire regimen using 1 tablet daily for 14 days, followed by 1 tablet twice a day. This is because the 14-day lead-in period has been observed to reduce the incidence of rashes in patients. Please note that Nevimune must be taken in combination with other antiretroviral agents to ensure the best outcome. Failure to do so might result in the emergence of a resistant virus. If you miss a dose, you should take it as soon as you remember, unless it is time for the next dose. In this case, continue with your regular schedule. You cannot take a double dose to compensate for any missed dose.
If you have moderate to severe hepatic impairment, as categorized by Child-Pugh Class B or C scores, you may not take this medication. This is due to the drug being metabolized by the liver via the cytochrome P450 isoenzymes. Besides this, it is also contraindicated for use as part of occupational and non-occupational post-exposure prophylaxis regimens to prevent HIV infections.
Nevimune Side Effects
Reported side effects include:
- Skin rash;
- Body chills;
- And the redistribution of body fat.
Severe side effects include:
- hepatic failure,
- Stevens-Johnson syndrome,
- toxic epidermal necrolysis,
- hypersensitive reactions.
Hepatitis or hepatic failure may be isolated or associated with signs of hypersensitivity.
These signs may include:
- severe rash or rash accompanied by fever,
- general malaise,
- muscle or joint aches,
- oral lesions,
- facial edema,
- lymphadenopathy, or renal dysfunction.
If you experience any rare side effects, please consult a healthcare provider immediately.
Do not drive or operate heavy machinery after taking this drug.
This medication has been known to interact with the following drugs and compounds:
- Alpha-blockers (e.g. doxazosin, prazosin);
- Antibiotics (e.g. erythromycin, rifampicin);
- Antifungals (e.g. ketoconazole);
- Anti-hypertensive drugs;
- Antiretroviral drugs (e.g. saquinavir, ritonavir);
- And nitrate drugs (e.g. nitroglycerin).
Pregnancy & Lactation
Nevimune is not recommended for use by pregnant women or patients who are breastfeeding.
If you accidentally overdose on this medication, obtain immediate medical treatment to prevent health complications. Do not change your dose unless directed by your doctor.
Nevimune is also sold under the brand name Viramune.
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