Lopimune is a medication used in the treatment of HIV with other antiretroviral medications. Each tablet of Lopimune contains 200mg of lopinavir and 50mg of ritonavir. Lopimune must be part of a daily regimen with other anti-HIV medications to prevent the progression of HIV to AIDS.
Lopimune tablets can be taken with or without food and must be swallowed whole. Patients starting anti-HIV therapy for the first time should take four tablets daily either all at once or two tablets in the morning and two at night. Patients with prior antiretroviral treatment and anyone taking nevirapine, fosamprenavir, amprenavir, nelfinavir or efavirenz should take two Lopimune pills in the morning and two at night; a once daily regimen is not recommended for these patients. An increase in dosing up to three tablets twice a day may be recommend in patients demonstrating poor susceptibility to Lopimune. The safety of Lopimune use for patients with renal or hepatic impairments is still being researched.
Those with prior history of hypersensitivity to ritonavir or lopinavir should avoid taking Lopimune. Lopimune should not be taken with the following medications: methylergonovine, antemizole, triazolam, terfenadine, midazolam, dihydroergotamine, ergonovine, ergotamine, cisapride or pimozide.
Diarrhea is the most commonly reported side effect by patients taking Lopimune, but many others have been documented including: redistribution of body fat digestive problems malaise back and chest pain cardiovascular abnormalities hypothyroidism Cushing's syndrome anaemia anxiety apathy diabetes mellitus lactic acidosis bone necrosis dizziness dyskinesia asthma pharyngitis skin discoloration loss of taste abnormal vision rhinitis sinusitis Several other side effects have been reported. Let a physician know if you start to notice changes in your health when starting Lopimune.
Patients sometimes experience symptoms of immune reconstitution syndrome when first starting Lopimune.
Lopimune can be co-administred with didanosine without food. Lopimune may decrease plasma concentrations of abacavir and zidovudine. Lopimune can worsen the side effects associated with fosamprenavir and tenofovir. Lopimune can hieghten plasma concentrations of drugs metabolized by the CYP3A isoform. Lopimune is known to increase the biotransformation of drugs that are metabolized by glucuronidation and cytochrome P450 enzymes. Lopimune may heighten concentrations of lipid lowering agents and antiarrhythmic drugs. Use only the lowest possible dosage of cerivastatin or atorvastatin with Lopimune. Consider substituting pravastatin or fluvastatin for these drugs. Taking Lopimune with simvastatin or lovastatincan cause myopathy. Co-administering phenobarbital, dexamethasone, carbamazepine or phenytoin may inhibit Lopimune's effectiveness. Lopimune may heighten serum concentrations of clarithromycin. Patients with renal patients may require dosing adjustment for Lopimune. Lopimune can heighten concentrations of tacrolimus, cyclosporine and sirolimus. Lopimune can increase concentrations of dihydropyridine calcium channel blockers. Lopimune can increase concentrations of azole, so patients taking Lopimune are advised not to use azole antifungals. Lopimune must no be co-administered with voriconazole because it can inhibit ritonavir's effectiveness. St. John's wort, or hypericum perforatum, can cause HIV to become permanently resistant to ritonavir. Do not use St. John's wort if you are taking Lopimune or other medications containing ritonavir. Lopimune may increase serum concentrations of warfarin. Lopimune can lower concentrations of the phosphodiesterase inhibitors tadalafil, vardenafil and sildenafil and may increase the probability of adverse effects associated with these drugs. Lopimune can affect steroid concentrations of ethinyl estradiol, commonly found in hormonal contraceptives. Those using Lopimune should consider non-hormonal alternatives.
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