Indivan is used to treat HIV-1. When taken regularly, Indivan can stop the progression of AIDS. In some cases of occupational exposures to HIV, Indivan has been successfully used in combination with other medications as chemoprophylaxis. Each tablet of Indivan contains 400mg of indinavir. Co-administration of other antiretroviral medications may be necessary to prevent HIV from replicating. Patients taking Indivan should have their viral load frequently monitored to ensure that treatment is effective.
Dosing & Administration
The recommended dose of Indivan is two pills, which equates to 800mg of indinavir, every eight hours without food.
Patients with a history of hypersensitivity to indinavir shouldn't use Indivan. Taking any of the following drugs with Indivan can lead to severe adverse effects and is therefore not recommended: alfuzosin, rifampin, amiodarone, dihydroergotamine, ergotamine, ergonovine, methylergonovine, lovastatin, cisapride, pimozide, simvastatin, sildenafil, atazanavir, triazolam, alprazolam or oral midazolam.
Several severe side effects have been reported by patients taking Indivan such as:
- kidney stones
- loss of red blood cells
- skin rash
- acute hemolytic anemia
- diabetes mellitus
- nephrolithiasis and renal insufficiency
- extreme fatigue
More side effects, such as redistribution of body fat, have been documented in patients taking Indivan. Inform a doctor immediately if you notice any health changes after beginning treatment.
Precautions and Warnings
Patients often experience symptoms of immune constitution syndrome when starting antiretroviral medications, but these symptoms go away within a couple of weeks. Patients with indirect hyperbilirubinemia, hemophilia A or B or hepatic insufficiency due to cirrhosis may need a reduced dose of Indivan because Indivan can heighten the risks these illnesses pose. Consuming eight glasses of water each day can help prevent the development of kidney stones.
Important Drug Interactions
Many drugs are known to interact with Indivan, so it is important to let your doctor know about all of the medications you use or plan to use. Some of the most commonly reported interactions are: Hypericum perforatum, better known as St. Johnâs wort, can cause HIV to become resistant to Indivan. Delavirdine may heighten plasma concentrations of Indivan. Co-administration may require altered doses of both drugs. Didanosine may be co-administered, but it must be taken at least a full hour after Indivan without food. Nelfinavir, saquinavir, efavirenz, nevirapine and ritonavir alter plasma concentrations of Indivan. A recommended dosage for co-administration of these drugs with Indivan is yet to be established. Indivan may heighten plasma concentrations of lidocaine, quinidine and bepridil. Carbamazepine, phenytoin andphenobarbital may lower plasma concentrations of Indivan and render Indivan ineffective. Indivan can exacerbate the side effects of trazodone. Lowering trazodone dose is recommended. Patients with renal or hepatic impairment must not co-administer colchicine with Indivan.
Pregnancy & Lactation
Indivan likely contaminates breast milk. Mothers with HIV should not breastfeed due to the risks of transmitting HIV to their infant.
Indivan is highly toxic in large quantities. Seek medical attention immediately if you take more Indivan than recommended.
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