Abamune is used as part of a regimen of anti-HIV medications to treat HIV-1. One tablet is comprised of abacavir sulphate equivalent to 300mg of abacavir. Abamune must be augmented with other antiretrovirals to prevent the progression of HIV-1 to AIDS.
Dosage & Administration
The recommended oral dose for HIV-1 infected adults is one 300mg tablet of Abamune twice daily along with other antiretroviral medications. Contrary to many anti-HIV drugs, no dosage adjustments are necessary for patients with renal complications. Patients between the ages of three months to 16 years can take 8mh/kg twice daily. Those with mild hepatic impairment defined as having a Child-Pugh score of 5 to 6 should only take 200mg twice every day. Abamune can be taken without regard to food.
Patients hypertensive to abacavir and patients with moderate to severe hepatic impairment should not take Abamune.
Mild side effects that have been associated with taking Abec are:
- mild elevation of blood glucose
- abdominal pain
Severe side effects that have been documented in patients taking Abamune are:
- altered liver function tests
- CPK elevations
- toxic epidermal necrolysis
- increased gamma glutamyl transferase
- Stevens- Johnson syndrome
- myocardial infarction
- body fat redistribution
- sleep disorders
- lactic acidosis
- hepatomegaly with steatosis
Abamune may cause other side effect. Inform your doctor immediately if you experience changes in your health after starting Abamune.
Warnings & Precautions
If hypersensitivity to abacavir cannot be ruled out, Abamune should be discontinued permanently. Anyone taking Abamune who is susceptible to liver disease may have a greater risk for hepatotoxicity and lactic acidosis. Extra precaution is necessary when prescribing Abamune to elderly patients. There is a possibility of cross resistance when taking Abamune in combination with other NRTIs.
Abamune has not been documented to affect cytochrome P450 isoforms, so the probability of Abamune interacting with medications that are metabolized through these pathways is insignificant.
Pregnancy & Lactation
In laboratory tests on pregnant animals, Abamune has been shown to increase the probability of birth defects. Human studies regarding risks of birth defects in pregnant women taking Abamune have yet to done, but the benefits of taking Abamune may warrent use in pregnant women. Mothers with HIV should avoid breastfeeding due to the possibility of transmitting HIV to their infants.
No known antidote for Abamune has been discovered, and it is unknown if Abamune can be removed through dialysis. Do not take more Abamune than prescribed.
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