- What is HIV/AIDS? Signs, Symptoms, Causes, and Treatment
- What is Isentress (Raltegravir) Used For? Side Effects and Dosage
- What is Intelence (Etravirine) Used For? Side Effects and Dosage
- What is Kaletra Medication Used For? Side Effects and Dosage
- What is Saquinavir (Invirase) Used For? Side Effects and Dosage
- What is Sustiva (Efavirenz) Used For? Side Effects and Dosage
- What is Finasteride (Propecia) Used For? Side Effects and Dosage
- What is Genvoya Used For? Side Effects and Dosage
- What is Evotaz Used For? Side Effects and Dosage
- What is Edurant (Riplivirine) Used For? Side Effects and Dosage
- What is Abacavir/Lamivudine Used For? Side Effects and Dosage
- What is Duovir Medication Used For? Side Effects and Dosage
- What is Hepatitis A? Signs, Symptoms, Causes and Treatment
- What is Hepatitis C? Signs, Symptoms, Causes and Treatment
- Different Types of HIV/AIDS Medications and Side Effects
- What is Tipranavir (Aptivus) Used For? Side Effects and Dosage
- What is Maraviroc (Celsentri) Used For? Side Effects and Dosage
- What is Descovy Medication Used For? Side Effects and Dosage
- What is Darunavir (Prezista) Used For? Side Effects and Dosage
- What is Complera Medication Used For? Side Effects and Dosage
- What is Lamivudine (Epivir) Used For? Side Effects and Dosage
- What is Combivir Medication Used For? Side Effects and Dosage
- What is PrEP HIV Prevention and What Are the Side Effects?
- What is Atazanavir Sulfate (Reyataz) Used For? Side Effects and Dosage
- What is Atripla Medication Used For? Side Effects and Dosage
- What is Abacavir Sulfate (Ziagen) Used For? Side Effects and Dosage
- Calanolide A: How it works?
- Truvada And Hepatitis B: Is It Safe to Take This Medicaiton?
- Immune globulin: What is it?
- Truvada Missed Dose: What to Do?
- Truvada Hair Loss: Why It Happens and How to Deal with It
- Truvada and Isentress: Effectiveness as HIV PEP Treatment
- Tivicay and Truvada
- Atripla Missed Dose: What to Do?
- How Does Truvada Work and How to Take it Properly
- What is the Difference Between Descovy Vs Truvada?
- Atripla Hair Loss: Why it happens and How to Best Deal With it
- Atripla and Alcohol: Interactions and What to do about it
- What is Truvada: Ingredients and Known Generics
- Truvada and Weight Loss: Why it Happens and How to Manage It
- Truvada Dosage: How to Take Truvada?
- Triumeq Generic: Find Out Everything about Triumeq Generic
- Truvada Side Effects: Most Common and How to Manage Them
- Atripla and Grapefruit: Interactions and How to Deal with It
- HIV Atripla Life Expectancy: Research Review
- Atripla Weight Gain: Why It Happens and How to Manage it?
- How effective are PrEP and PEP?
- Genvoya Interactions
- Can Genvoya Be Crushed?
- Genvoya vs Truvada: What is the Real Difference?
- Switching from Atripla to Genvoya
- Can Triumeq Be Crushed? Recommendations for Taking Triumeq
- Triumeq Food Interactions
- Changing from Atripla to Triumeq
- Triumeq vs Atripla
- Genvoya vs Complera
- Triumeq vs Truvada: What is the Difference?
- Does Stribild Cause Weight Gain?
- Atripla and Diarrhea
- What Medicines Should Not Be Taken with Stribild?
- Triumeq vs Genvoya
- Genvoya vs Odefsey
- Triumeq Drug Interactions
- Odefsey vs Atripla
- Triumeq Dosage
- Triumeq and Weight Gain
- Triumeq and Alcohol
- What is Stribild Used For
- What is Triumeq Used For? Explained
- Genvoya Weight Gain
- Genvoya vs Atripla
- Genvoya vs Stribild - Costs, Side Effects & Why Switching To Genvoya
- Triumeq Side Effects Treatment Risks and Benefits
- What is Triumeq? Ingredients and Dosage
- Genvoya and Alcohol Consumption
- HIV & Coronary Artery Disease
- HIV & Dyslipidemia
- HIV & Hepatitis
- HIV & Cognitive Impairment
- HIV and Hypogonadism - AIDS Drugs Online
- HIV & Thromboembolic Disease
- HIV & Sudden Cardiac Death
- HIV & Hypertension
- HIV & Thyroid Disease
- Can I buy Finasteride over the counter? Question Resolved
What is Triumeq? Ingredients and Dosage
What is Triumeq?
Triumeq is a single-tablet regimen (STR) approved by the US Food and Drug Administration for the treatment of HIV-1 infection in adults and children weighing at least 40kgs (88lbs). It contains a combination of 2 nucleoside analogue reverse transcriptase inhibitors abacavir and lamivudine, and an integrase strand transfer inhibitor (INSTI) dolutegravir.
At the time of this writing, there are currently 7 once-daily, complete single-pill regimen approved by the FDA to treat HIV-infected patients. Triumeq was the fourth STR to be granted approval in 2014. The advent of combination antiretroviral therapies (ART) significantly improved patient survival and minimizes viral resistance. The newest update from the Department of Health and Human Services guideline recommends that all HIV-infected individuals must begin ART, regardless of CD4 cell count. Single-pill regimens may provide beneficial effects on patients:
- Who have not received antiretroviral medications in the past;
- Who would like to reduce pill burden from the same or similar individual HIV medications;
- Who would like to shift from a complicated or poorly-tolerated regimen and have not developed resistance to any of the components of these STRs.
- Dolutegravir – is an integrase inhibitor that interferes with HIV replication.
- Abacavir – a nucleotide analogue reverse transcriptase inhibitor that blocks the viral enzyme reverse transcriptase from converting RNA into DNA.
- Lamivudine – a nucleotide analogue that inhibits reverse transcription of HIV by terminating the viral DNA chain.
D-mannitol, magnesium stearate, microcrystalline cellulose, povidone, and sodium starch glycolate.
Tablet film-coating ingredients:
Iron oxide black, iron oxide red, macrogol/PEG, polyvinyl alcohol–part hydrolyzed, talc, and titanium oxide.
Triumeq (dolutegravir/abacavir/lamivudine) is available in a 30-tablet bottle. Each pill contains 600mg abacavir sulfate (ABC), 50mg dolutegravir (DTG), and 300mg lamivudine. (3TC). Patients without known HIV resistance to any components of Triumeq must take 1 tablet once a day, with or without food. The presence of abacavir requires hypersensitivity pretreatment testing. Being a complete ARV regimen, it should not be combined with other HIV medications that contain any of its active ingredients.
How does Triumeq work?
The combination of dolutegravir (marketed as Tivicay), abacavir (Ziagen), and lamivudine (Epivir) has done well in many clinical trials in terms of potency and tolerability. Dolutegravir itself has no major disadvantage. People who have used DTG as an initial regimen have not exhibited resistance to the drug.
Dolutegravir works by inhibiting the HIV enzyme integrase, which occurs when its active metabolite binds to the integrase active site and blocks the strand transfer stage of retroviral DNA integration. Carbovir triphosphate, the active metabolite of abacavir, inhibits the activity of HIV-1 enzyme reverse transcriptase. Lamivudine is introduced within cells to be converted into its metabolite, lamivudine triphosphate. It works by inhibiting the activity of reverse transcriptase through DNA chain termination.