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Odefsey Uses, Side Effects and Dosage

Odefsey Uses, Side Effects and Dosage

What is Odefsey?

Odefsey is a medication by the manufacturer Gilead Sciences Inc. that is used to treat HIV in infected individuals. It consists of three active ingredients in one tablet: emtricitabine, rilpivirine, and tenofovir alafenamide. It is indicated as a complete treatment regimen for HIV-1 infection. Odefsey is the brand name for this particular drug class; no generic version is currently available.

What is this medication used for?

When used correctly, the three drugs in Odefsey – emtricitabine, rilpivirine, and tenofovir alafenamide–work in concert to interfere with the replication of HIV in human T-cells. This reduces the concentration of viral particles in the bloodstream, otherwise known as the viral load.

How does this drug work?

Odefsey contains three separate drugs that contain two main types of active ingredients: an HIV nucleoside analog reverse transcriptase inhibitors (NRTI) and a non-nucleoside reverse transcriptase inhibitor (NNRTI). These two medications work in concert to interfere with HIV’s replication mechanism once it is inserted into human T-cells. This reduces the number of viral particles in the blood, also known as viral load.

How to take it

Odefsey is taken once a day as a tablet containing a fixed dosage of 200mg emtricitabine, 25mg rilpivirine (as rilpivirine hydrochloride), and 25mg tenofovir alafenamide (as tenofovir alafenamide hemifumarate). The drug must be taken with food to increase the bioavailability of the active ingredients. This medication is not indicated for pediatric (<18 years of age) patients. Use of Odefsey by geriatric patients (≥ 65 years of age) should be initiated under the guidance of a physician. If a patient misses a dose of Odesfey, they should take the next dose as soon as possible, with a meal, then take the subsequent dose after the recommended time interval. If the patient misses the dosing window by more than 12 hours, they should not make up for the skipped dose. If a patient vomits within four hours of taking Odesfey, they should take another tablet right away with a meal.

Odefsey side effects

In several large clinical trials in adult patients infected with HIV-1, Odesfey was generally well-tolerated. However, patients with hepatitis B infection (HPB), several acute exacerbations of HPB (i.e. liver decompensation and liver failure) were documented which required ceasing the administration of Odefsey. Patients with HPV infection must consult closely with a physician and undergo regular hepatic testing if they are prescribed Odefsey.

Common side effects

  • Headache
  • Sleep disorders
  • Nausea

Serious side effects

  • Hepatoxicity
  • Renal impairment
  • Depressive disorders

Dosage

Each tablet of Odefsey contains 200mg emtricitabine, 25mg rilpivirine (as rilpivirine hydrochloride), and 25mg tenofovir alafenamide (as tenofovir alafenamide hemifumarate). One tablet of Odefsey should be taken at the same time each day with a meal. Taking this drug with food is important, as this increases the bioavailability of the active ingredients.

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