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What is Maraviroc (Celsentri) Used For? Side Effects and Dosage

What is Maraviroc (Celsentri) Used For? Side Effects and Dosage

What is Maraviroc (Celsentri)?

Maraviroc is an antiretroviral drug in the class of CCR5 antagonist or entry inhibitors. Sold under the brand name Selzentry in the U.S. and Celsentri outside of the U.S., it is used in combination with other anti-HIV medications. Selzentry is manufactured by Pfizer.

What is This Medication Used For?

Maraviroc is used to treat HIV by preventing the virus from infecting healthy cells. Maraviroc’s mechanism of action works by protecting cells before they are infected, whereas many other approved HIV drugs work by interfering with cells after they have already been infected. The drug is used to block access to a molecule called CCR5, which is found in cells in the immune system. By blocking access to CCR5, HIV cannot enter the cell to infect it with the virus.

Celsentri is used in antiretroviral therapy, or ART, which is when a combination of anti-HIV medications, including those from the drug classes nucleoside analogues, non-nucleoside reverse transcriptase inhibitors, and protease inhibitors, are taken together.

How to Take Celsentri

Maraviroc tablets can be taken with or without food, in combination with other anti-HIV drugs. This medication is taken orally and should be swallowed whole, with no chewing, crushing, or spitting involved.

Maraviroc Side Effects

While maraviroc is a safe and effective treatment for HIV, there have been some adverse effects reported with its use.

Common Side Effects

  • Cough
  • Fever
  • Muscle pain
  • Rash
  • Lung infection
  • Stomach pain
  • Dizziness
  • Constipation
  • Difficulty sleeping

Severe Side Effects

  • Liver damage (symptoms include itchy rash, yellow skin or eyes, dark urine, vomiting, stomach pain)
  • Hypersensitivity reactions
  • Skin reactions
  • Cardiac events (myocardial ischemia or infarction)

If you experience any severe side effects, call your doctor immediately.

Dosage

Maraviroc comes in 150 mg and 300 mg tablets. A doctor will determine your dosage depending on the other medications in your ART combination.

Drug Interactions

Maraviroc may interact with several drugs, including other antiretroviral medications. These interactions can increase or decrease the amount of maraviroc in your body, which means that your doctor will need to adjust your dosage based on what other medications you are taking. Patients taking this drug should not use the herbal supplement St. John’s Wort.

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