What is Darunavir (Prezista) Used For? Side Effects and Dosage

What is Darunavir (Prezista) Used For? Side Effects and Dosage

What is Darunavir (Prezista)?

Darunavir is an antiretroviral drug that is sold under the brand name Prezista. It is used in combination with other HIV therapy medications and is classified as a protease inhibitor drug. Prezista is manufactured by Janssen Therapeutics, a division of Janssen Products.

What is This Medication Used For?

Prezista is used with other antiretroviral medications to treat HIV. Though there is currently no cure for HIV, antiretroviral therapy (ART) helps reduce the spread of HIV within the blood. As a protease inhibitor, Darunavir interferes with the enzyme protease. Protease is used by HIV-infected cells to make copies of the virus and spread it throughout the body. When the enzyme is inhibited, it slows or stops the spread of new viruses. 

How to Take Prezista

Prezista medication comes in oval tablets that are taken orally. To ensure that the drug is absorbed, Darunavir must be taken with food. If you forget a dosage and realize your mistake within 12 hours, take Darunavir immediately. If you forget a dose and notice after 12 hours or more have passed, wait for the next dosage and take it at the usual time. Do not take two doses at the same time.

Darunavir Side Effects

Darunavir has been tested and proved for safety and effectiveness. However, adverse effects do sometimes occur.

Common Side Effects

  • Diarrhea
  • Nausea
  • Vomiting
  • Heartburn
  • Stomach pain
  • Weakness
  • Headache
  • Skin rash

Severe Side Effects

  • Liver problems
  • Severe skin reactions


The standard adult dose is one 800mg pill of Darunavir taken once daily. Always take Darunavir with a meal. This medication must also be taken with other anti-HIV medications, such as Ritonavir.

Drug Interactions

You must discuss with your doctor any other prescription or non-prescription drugs you are taking before using Darunavir, as it is known to have several drug interactions.

The manufacturer recommends that Prezista drug should not be taken if you are already on any of the following drugs:

  • Drugs for prostate problems, such as Alfuzosin (Xatral)
  • Drugs for abnormal heart rhythm, such as Amiodarone, Dronedarone, Lidocaine (injected into the body), Quinidine
  • Drugs for reducing the risk of blood clots, such as Apixaban, Rivaroxaban, Ticagrelor
  • Anti-seizure drugs such Ascarbamazepine, Phenobarbital, Phenytoin
  • Gout drugs, such as Colchicine
  • Antihistamines, such as Astemizole, Terfenadine
  • Antibiotics, such as Rifampin
  • Drugs for migraines, such as Dihydroergotamine, Ergonovine, Ergotamine, Methylergonovine
  • Drugs for hepatitis C, such as Zepatier (Elbasvir + Grazoprevir)
  • Drugs for high cholesterol, such as Lovastatin, Simvastatin
  • Drugs for treating asthma and other lung issues, such as Salmeterol (Advair, Advair Diskus, Serevent Diskhaler Disk, Serevent Diskus)
  • Anti-psychosis drugs such as Lurasidone (Latuda), Pimozide
  • Drugs for pulmonary arterial hypertension, such as Sildenafil (Revatio)
  • Sleep aids, such as Midazolam, Triazolam
Disclaimer: Please note that the contents of this article are for informational purposes only and should not be considered medical advice. This article, and other AIDS and HIV Information articles on AIDS Drugs Online, are not written by AIDS Drugs Online or reviewed by its staff for medical validity. All views and opinions expressed by the third-party authors are not endorsed by AIDS Drugs Online or its staff. Always consult a medical professional for medical advice.


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